Barbara L. Parry, M.D. 

Professor of Psychiatry

Parry Lab

Contact Information

9500 Gilman Drive, La Jolla,
CA 92037-0804
T: (619) 543-5592
F: (619) 543-7519
bparry@ucsd.edu

Biography

Barbara L. Parry, M.D. is Professor of Psychiatry at the University of California, San Diego (UCSD) where she is Director of the Women’s Mood Disorders Clinic at the Outpatient Psychiatric Service, Director of the Women’s Mental Health Clinic at the San Diego Veterans Affairs Healthcare System and Associate Director of the Medical Student Clerkship in Psychiatry. Before joining the faculty at UCSD in 1985, she did a research fellowship at the National Institute of Mental Health in Clinical Psychobiology. She completed a residency in psychiatry and an internship in internal medicine at the University of California, Los Angeles. Her clinical research focus is the chronobiology of mood disorders specific to women: premenstrual, pregnancy/postpartum and menopausal depression. She conducts sleep, light, melatonin and other hormonal studies with the aim of developing non-pharmacological approaches to treatment.

Research Interests

Research Focus

My research and clinical background is in women’s mood disorders related to the reproductive cycle, and in chronobiology: With regard to my background in women’s mood disorders, as a medical student, I published a manuscript on the biologic basis of oral contraceptive-induced depressions (Mentor: A. John Rush, M.D.); as a psychiatric resident at the University of California, Los Angeles, I initiated, and subsequently published, a study on cerebrospinal fluid and endocrine measures in Premenstrual Dysphoric Disorder-PMDD (Mentor: Robert Gerner, M.D.). I continued my studies of women’s mood disorders at the NIH, expanding into its chronobiological aspects, and for the last 29 years since coming to UCSD have extended the endocrine and chronobiological investigations in PMDD to other depressive disorders related to the reproductive cycle in women (pregnancy, postpartum, menopause). With regard to chronobiology, I did a research fellowship in Clinical Chronobiology at the National Institute of Mental Health (Mentors: Frederick K. Goodwin, M.D., Thomas A. Wehr, M.D. and Norman E. Rosenthal, M.D.), where as a clinical research associate I helped to implement studies primarily of melatonin circadian rhythms and of sleep and light therapies in mood disorders (rapid cycling bipolar illness and seasonal affective disorder) and initiated my own studies on melatonin circadian rhythms, sleep and light therapies in PMDD. Since joining the faculty in the Department of Psychiatry at the University of California, San Diego (UCSD) in 1985, I have extended the studies of melatonin and other hormones (cortisol, thyroid, prolactin, estradiol, progesterone, gonadotrophins) and of sleep and light therapies to not only PMDD, but also to pregnancy, postpartum and menopausal depressive disorders (Collaborators: J. Christian Gillin, M.D., Daniel F. Kripke, M.D., Richard L. Hauger, M.D., Jeffrey A. Elliott, Ph.D., Sonia Ancoli-Israel, Ph.D.). I served on the American Psychiatric Association’s DSM-III-R and DSM-IV committees to develop diagnostic criteria for PMDD (and as a consultant for postpartum mood disorders), the Advisory Panel for the Surgeon General’s Women’s Mental Health Project, the NIH Office of Research for Women’s Health: Planning the Women’s Health Agenda for the 21st Century and the Executive Board of the Marce’ Society, The International Society for the Study and Treatment of Mental Illness during Childbearing. In these areas pertaining to the chronobiology of women’s mood disorders, I have published over 285 publications, maintained a consistent level of funding support through primarily NIH and other sources as PI, served as a reviewer on study sections, special emphasis panels, stimulus package grant applications and Data and Safety Monitoring Boards, and been on the editorial boards of multiple journals including the American Journal of Psychiatry, the Journal of Biological Rhythms, the International Journal of Endocrinology and Postpartum Equilibria: Journal of Postpartum Depression Research.

Publications

  • Parry BL , Wehr TA. Therapeutic Effects of Sleep Deprivation in PMS Patients. American Journal of Psychiatry 144:808-810, 1987.
  • Parry BL, Berga SL and Mostofi N, et al: Morning vs. Evening Bright Light Treatment of Late Luteal Phase Dysphoric Disorder. Am J Psychiatry 146:1215-1217, 1989.
  • Parry BL, Berga SL, Kripke DF et al: Altered Waveform of Plasma Nocturnal Melatonin Secretion in Premenstrual Depression. Archives of General Psychiatry, 47:1139-1146, 1990.
  • Parry BL, Mahan AM, Mostofi N et al. Light Therapy of Late Luteal Phase Dysphoric Disorder: An Extended Study. Am J Psychiatry 150(9):1417-1419, 1993.
  • Parry BL , Hauger R, Lin E, et al: Neuroendocrine Effects of Light Therapy in Late Luteal Phase Dysphoric Disorder, Biological Psychiatry 36:356-364, 1994.
  • Parry BL, Cover H, Mostofi N, et al: Early vs. Late Partial Sleep Deprivation in Premenstrual Dysphoric Disorder and Normal Control Subjects. Am J Psychiatry, 152:404-412, 1995.
  • Parry BL, Hauger R, LeVeau B, et al. Prolactin and TSH Circadian Rhythms During the Menstrual Cycle and Early vs. Late Sleep Deprivation in Premenstrual Dysphoric Disorder and Normal Comparison Subjects. Psychiatry Research, 62:147-160, 1996.
  • Parry BL, LeVeau B, Mostofi N, Naham HC, Loving R, Clopton P, Gillin JC. Temperature Circadian Rhythms During the Menstrual Cycle and Sleep Deprivation in Premenstrual Dysphoric Disorder and Normal Comparison Subjects. J Biological Rhythms, 12(1):34-46, 1997.
  • Parry BL, Berga SL, Mostofi N, Klauber MR, Resnick A. Plasma Melatonin Circadian Rhythms During the Menstrual Cycle and After Light Therapy in Premenstrual Dysphoric Disorder and Normal Control Subjects. J Biological Rhythms, 12(1): 47-64, 1997.
  • Parry BL, Udell C, Elliott J et al: Blunted Phase-Shift Responses to Morning Bright Light in Premenstrual Dysphoric Disorder. J Biological Rhythms, 12(5): 443-456, 1997.
  • Parry BL, Mostofi N, LeVeau B et al. Sleep EEG Studies and During Early and Late Partial Sleep Deprivation in Premenstrual Dysphoric Disorder and Normal Control Subjects. Psychiatry Research, 85(2): 127-143, 1999.
  • Parry BL, Javeed S, Laughlin G, Hauger R, Clopton P: Cortisol circadian rhythms during the menstrual cycle and with sleep deprivation in premenstrual dysphoric disorder and normal control subjects. Biological Psychiatry, 48: 920-931, 2000.
  • Parry BL, Meliska CJ, Martinez LF, Lopez AM, Sorenson DL, Hauger RL, Elliott JA: Late, but not early, wake therapy reduces morning plasma melatonin: relationship to mood in Premenstrual Dysphoric Disorder. Psychiatry Research, 161: 76-86, 2008. NIHMSID242664
  • Parry BL, Meliska CJ, Sorenson DL et al: Increased sensitivity to light-induced melatonin suppression in Premenstrual Dysphoric Disorder. Chronobiology International 27(7): 1438-1453, 2010. PMC2190736
  • Parry BL, Meliska CJ, Sorenson DL, Martinez LF, Lopez AM, Elliott JA, Hauger RL. Reduced phase-advance of plasma melatonin after bright morning light in the luteal, but not follicular, menstrual cycle phase in premenstrual dysphoric disorder: an extended study. Chronobiol Int. 2011;28(5):415-424. NIHMS329896.