University of California, San Diego
Department of Psychiatry
9500 Gilman Drive
La Jolla, CA 92093-0603
T: (858) 534-3684
F: (858) 534-7653
Igor Grant, M.D., is Distinguished Professor and Chair of the Department of Psychiatry at the University of California, San Diego School of Medicine. Dr. Grant is a neuropsychiatrist who trained at the University of British Columbia and the University of Pennsylvania before joining UCSD. His research interests include the effects of various diseases, such as HIV/AIDS and abuse of drugs and alcohol on the brain and behavior, as well as the psychobiological effects of chronic stress on the elderly. He is recipient of awards for excellence in teaching and his contributions to neuropsychology.
A major theme of Dr. Grant’s research concerns the effects of systemic and neurological diseases, as well as substance abuse, on brain function and structure. His current research focus is on the effects of HIV on the brain and the potential that abuse of certain drugs, such as methamphetamine, in combination with aging, produce accelerated CNS injury. His work is supported by multiple NIH awards, including a P50 Center from NIDA entitled, the Translational Methamphetamine AIDS Research Center (TMARC). His other major studies include the CNS HIV Antiretroviral Therapy Effects Research (CHARTER) study, the California NeuroAIDS Tissue Network, a project in St. Petersburg Russia on the effects of opioid withdrawal on HIV controls. He is also Co-Director of the HIV Neurobehavioral Research Center and Director of the Center for Medical Cannabis Research. His past work on brain and behavior has included long-term outcome studies with alcoholics, persons suffering from chronic obstructive pulmonary disease with hypoxia, multiple sclerosis, and traumatic brain injury.
Another theme of Dr. Grant’s work has been on the effects of chronic stress on physiologic and behavioral function. The most recent work has focused on the chronic stress of caregiving for a dementia relative with studies on cardiovascular, inflammatory, and psychological effects of such caregiving. These studies have been funded by sequential awards from the National Institute on Aging.
Clinical and Teaching Focus
Dr. Grant has been involved in all levels of teaching at UCSD. He organized, and for many years led the UCSD School of Medicine’s course in Social and Behavioral Sciences, and currently teaches as a facilitator in the Mind, Brain, Behavior core course. He actively mentors graduate students in the SDSU/UCSD Joint Doctoral Program in Clinical Psychology and has served as dissertation chair for 32 trainees. He has also been a supervisor of postdoctoral trainees, medical students working on their Independent Study Project, and junior faculty.
After being recruited to San Diego, Dr. Grant helped establish the first VA mental health clinic at the UCSD affiliated San Diego VA Medical Center. Thereafter, he served as Director of the Psychiatry Department’s Outpatient Clinic (Gifford Mental Health Clinic) and also as Head of the Consult/Liaison Service at the San Diego VA Medical Center.
Currently, Dr. Grant’s clinical work is limited to periodic consultations on patients with complex neuropsychiatric problems where there is an interest to sort out the separate and combined effects of brain injury and psychopathology on behavior.
- Grant I, Franklin DR, Deutsch R, Woods SP, Vaida F, Ellis RJ, Letendre SL, Marcotte TD, Atkinson JH, Collier AC, Marra CM, Clifford DB, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Abramson I, Gamst A, Fennema-Notestine C, Smith DM, Heaton RK, for the CHARTER Group. (2014). Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline. Neurology, 82(23), 2055-2062.
- Iudicello JE, Morgan EE, Gongvatana A, Letendre SL, Grant I, Woods SP. (2014). Detrimental impact of remote methamphetamine dependence on neurocognitive and everyday functioning in older but not younger HIV+ adults: Evidence for a legacy effect? Journal of Neurovirology, 20(1), 85-98.
- Blackstone K, Iudicello JE, Morgan EE, Weber E, Moore DJ, Franklin D, Ellis RJ, Grant I, Woods SP, and the TMARC Group. (2013). HIV infection heightens concurrent risk of functional dependence in persons with chronic methamphetamine use. Journal of Addiction Medicine, 7(4), 255-263.
- von Känel R, Mausbach BT, Mills PJ, Dimsdale JE, Patterson TL, Ancoli-Israel S, Ziegler MG, Allison M, Chattillion EA, Grant I. (2013). Longitudinal relationship of low leisure satisfaction but not depressive symptoms with systemic low-grade inflammation in dementia caregivers. Journal of Gerontology: Psychological Science, 69(3), 397-407
- Cattie JE, Woods SP, Iudicello JE, Posada C, Grant I, and the TMARC Group. (2012). Elevated neurobehavioral symptoms are associated with poorer everyday functioning problems in chronic methamphetamine users. Journal of Neuropsychiatry and Clinical Neurosciences, 24(3), 331-339.
- Mausbach BT, Chattillion E, Roepke SK, Ziegler MG, Milic M, von Känel R, Dimsdale JE, Mills PJ, Patterson TL, Allison MA, Ancoli-Israel S, Grant I. (2012). A longitudinal analysis of the relations among stress, depressive symptoms, leisure satisfaction, and endothelial function in caregivers. Health Psychology, 31(4), 433-440.
- von Känel R, Mausbach BT, Ancoli-Israel S, Dimsdale JE, Mills PJ, Patterson TL, Ziegler MG, Roepke SK, Chattillion EA, Allison M, Grant I. (2012). Sleep in spousal Alzheimer caregivers: A Longitudinal study with a focus on the effects of major patient transitions on sleep. Sleep, 35(2), 247-55.
- von Känel R, Mausbach BT, Dimsdale JE, Mills PJ, Patterson TL, Ancoli-Israel S, Ziegler MG, Roepke SK, Chattillion EA, Allison M, Grant I. (2012). Effect of chronic dementia caregiving and major transitions in the caregiving situation on kidney function: A longitudinal study. Psychosomatic Medicine, 74(2), 214-220.
- Roepke SK, Allison M, von Känel R, Mausbach BT, Chattillion EA, Harmell AL, Patterson TL, Dimsdale JE, Mills PJ, Ziegler MG, Ancoli-Israel S, Grant I. (2012). Relationship between chronic stress and carotid intima-media thickness (IMT) in elderly Alzheimer's Disease caregivers. Stress, 15(2), 121-129.
- Gendelman HE, Grant I, Everall IP, Fox HS, Gelbard HA, Lipton SA, and Swindells S (Eds.). (2011) The Neurology of AIDS, 3rd edition. New York: Oxford University Press
- Grant I, Adams KM, (Eds). (2009). Neuropsychological Assessment of Neuropsychiatric and Neuromedical Disorders, 3rd edition. New York: Oxford University Press.
- Marcotte TD and Grant I. (Eds.) (2009). Neuropsychology of Everyday Functioning. New York: Guilford Press.