Lisa T. Eyler, Ph.D. 

Associate Professor


Contact Information

Mail Code 151B
3500 La Jolla Village Drive
San Diego, CA 92161
T: (858) 552-8585, Ext. 7666
F: (858) 642-1458


Dr. Eyler received her undergraduate degree from Duke University in 1991 and her PhD in clinical psychology from the University of Pennsylvania in 1996. She then completed a clinical psychology internship at UC San Diego and the San Diego VA, with a focus on neuropsychological assessment and adult outpatient psychotherapy. From 1997-1999, she was a post-doctoral fellow in Geriatric Psychology under the mentorship of Dilip Jeste, M.D. and Gregory Brown, Ph.D. She then joined the faculty of the Desert-Pacific Mental Illness Research Education and Clinical Center (MIRECC) as a Research Health Scientist. In 2004, she was appointed an Assistant Professor in the UCSD Department of Psychiatry, and, in 2010, became an Associate Professor. Dr. Eyler also is a Clinical Research Psychologist in the MIRECC program and is Associate Director of the MIRECC Neuroimaging Unit. In addition, she serves as a faculty member in the SDSU/UCSD Joint Doctoral Program in Clinical Psychology and the Stein Institute for Research on Aging. Dr. Eyler is chair of the Psychiatry Department Chair’s Advisory Committee on Diversity Issues and chair of the UCSD School of Medicine’s Standing and Promotions Committee. Dr. Eyler’s research program is currently supported by several NIH grants on which she is an investigator, including an R01 grant from NIMH entitled "Structural and Functional Brain Aging in Bipolar Disorder" on which she is Principal Investigator.

Research Interests

Research Focus

Dr. Eyler's research focuses on understanding individual differences in cognitive and emotional functioning using structural and functional brain imaging. In particular, she has examined the relationship between cognitive deficits in schizophrenia and abnormalities of brain function and how these relationships may change with age. Her current NIMH-funded R01 project aims to examine whether brain structure and function appear to age more rapidly among individuals with bipolar disorder and how this may relate to increasing cognitive deficits with age. Dr. Eyler is also a co-investigator in the Autism Center of Excellence at UCSD and is involved in studies that aim to discover a bio-behavioral fingerprint of autism at a very young age by combining neuroimaging, behavioral, and genetic measures in infants and toddlers at risk for autism to improve diagnostic predictions and better understand the developmental etiology of the disorder. Dr. Eyler also has an interest in healthy aging and has conducted studies examining the relationship of cognitive and emotional success to brain function among healthy seniors, and she is a co-investigator on the Vietnam Era Twin Study of Aging MRI study which aims to understand genetic and environmental contributions to brain aging and its association with cognitive and emotional functioning.

Clinical Focus

Dr. Eyler is a licensed clinical psychologist with training in neuropsychological and diagnostic assessment and adult outpatient psychotherapy.


  • Eyler LT, Jeste DV, Brown GG (2008). Brain response abnormalities during verbal learning among patients with schizophrenia. Psychiatry Research: Neuroimaging, 162 (1), 11-25.
  • Eyler LT, Kaup AR, Mirzakhanian H, Jeste DV (2009). Schizophrenia patients lack normal positive correlation between age and brain response during verbal learning. American Journal of Geriatric Psychiatry, 17 (1), 43-55.
  • Eyler LT, Prom-Wormley E, Fennema-Notestine C, Panizzon MS, Neale MC, Jernigan TL, Fischl B, Franz CE, Lyons MJ, Makris N, Pacheco J, Perry ME, Schmitt JE, Spitzer N, Seidman LJ, Thermenos H, Tsuang MT, Dale AM, Kremen WS (2011.) Genetic patterns of correlation among subcortical volumes in humans: Results from a magnetic resonance imaging twin study. Human Brain Mapping, 32(4), 641-53.
  • Eyler LT, Sherzai A, Kaup AR, Jeste DV (2011). A review of functional brain imaging correlates of successful cognitive aging. Biological Psychiatry, 70: 115-122.
  • Eyler LT, Prom-Wormley E, Panizzon MS, Kaup AR, Fennema-Notestine C, Neale MC, Jernigan TL, Fischl B, Franz CE, Lyons MJ, Grant M, Stevens A, Pacheco J, Perry ME, Schmitt JE, Seidman LJ, Thermenos HW, Tsuang MT, Chen C, Thompson WK, Jak A, Dale AM, Kremen WS. (2011). Genetic and environmental contributions to regional cortical surface area in humans: A magnetic resonance imaging twin study. Cerebral Cortex, 21(10): 2313-21.
  • Bangen KJ*, Kaup AR, Mirzakhanian H, Wierenga CE, Jeste DV, Eyler LT (2012). Compensatory brain activity during encoding among older adults with better recognition memory for face-name pairs: An integrative functional, structural, and perfusion imaging study. Journal of the International Neuropsychological Society, 20:1-19.
  • Eyler LT, Pierce K, Courchesne E [co-equal first authors] (2012). A failure of left temporal cortex to specialize for language is an early emerging and fundamental property of autism. Brain, 135(Pt 3):949-60.
  • Chen CH, Gutierrez ED, Thompson W, Panizzon MS, Jernigan TL, Eyler LT, Fennema-Notestine C, Jak AJ, Neale MC, Franz CE, Lyons MJ, Grant MD, Fischl B, Seidman LJ, Tsuang MT, Kremen WS, Dale AM. (2012). Hierarchical genetic organization of human cortical surface area. Science, 335(6076):1634-6.
  • McKenna BS*, Eyler LT. (2012). Overlapping prefrontal systems involved in cognitive and emotional processing in euthymic bipolar disorder and following sleep deprivation: A review of functional neuroimaging studies. Clinical Psychology Review, 32(7):650-663.
  • Bangen KJ*, Bergheim M, Kaup AR, Mirzakhanian H, Wierenga C, Jeste D, Eyler LT. (2014). Brains of optimistic older adults respond less to fearful faces. Journal of Neuropsychiatry and Clinical Neurosciences, 26(2): 155-63.
  • Eyler LT, Vuoksimaa E, Panizzon MS, Fennema-Notestine C, Neale MC, Chen CH, Jak A, Franz CE, Lyons MJ, Thompson WK, Spoon KM, Fischl B, Dale AM, Kremen WS. (2014). Conceptual and data-based investigation of genetic influences and brain asymmetry: A twin study of multiple structural phenotypes. Journal of Cognitive Neuroscience, 26(5): 1100-17.
  • McKenna BS*, Sutherland AN, Legenkaya AP, Eyler LT. (2014). Abnormalities of brain response during encoding into verbal working memory among euthymic bipolar patients. Bipolar Disorders, 16(3): 289-99.
  • Moore RC*, Sirkin Martin A, Kaup AR, Thompson WK, Peters ME, Jeste DV, Goshan S, Eyler LT. (2014) From suffering to caring: A model of differences among older adults in levels of compassion. International Journal of Geriatric Psychiatry.
  • McKenna BS*, Drummond SP, Eyler LT. (2014) Associations between circadian activity rhythms and functional brain abnormalities among euthymic bipolar patients: A preliminary study. Journal of Affective Disorders.