Michael P. Caligiuri, Ph.D. 

Professor Emeritus

 

Contact Information

8950 Villa La Jolla Drive, Suite A-208
La Jolla, CA 92037
T: (858) 455-5050
F: (858) 455-9540
mcaligiuri@ucsd.edu

Biography

Dr. Caligiuri attended the University of Wisconsin, Madison where he received a Ph.D. in neuroscience with an emphasis in motor control. His current research focuses on motor control in neuropsychiatric disorders, developing quantitative instrumentation for assessing dyskinesia and parkinsonism, and understanding the interplay between neuromotor dyscontrol and psychiatric illness.  Particular emphasis is placed on validating measures of handwriting kinematics for quantitative assessment of neuropsychiatric movement disorders.

Research Interests

Research Focus

Dr Caligiuri’s research focuses on understanding how motor function and impairment can be useful in the diagnosis and treatment of affective and psychotic illnesses. Significant research contributions include: the demonstration that early drug-induced parkinsonism can predict long-term persistent movement disorders in patients treated with antipsychotics; finding that affective state in bipolar disorder may be related to a disturbance of inhibitory regulation within the basal ganglia and that antipsychotics and or mood stabilizers normalize cortical and subcortical hyperactivity in patients with bipolar disorder; development of a portable, simple to use transducer for quantifying tremor; and demonstrating that measures of handwriting kinematics can detect subtle differences in EPS liability between various antipsychotic medications. His current research aims to understand the effects of drugs, disease, and aging on handwriting kinematics to enable the forensic community to better understand these contributions when authenticating signatures.

Clinical Focus

Dr. Caligiuri’s clinical focus is on movement disorders with particular emphasis of differentiating idiopathic or degenerative disorders from medication-induced disorders and developing technologies for the rapid quantification of extrapyramidal motor signs such as tremor, dyskinesia and bradykinesia.

Publications

  • Cortese, L Caligiuri, MP, Malla, AK, Manchanda, R, Takhar J, Haricharan, R. (2005) Relationship of neuromotor disturbances to psychosis symptoms in first-episode neuroleptic-naïve schizophrenia patients. Schizophrenia Research 75: 65-7
  • Lohr LB, Caligiuri MP (2006) Abnormalities in Motor Physiology in Bipolar Disorder. J Neuropsychiatry Clin Neurosci. 18(3):342-9.
  • Caligiuri MP, Brown GG, Meloy MJ, Eberson S, Niculescu AB, Lohr JB (2006) Striatopallidal regulation of affect in bipolar disorder. J Affect Disord. 2006 Apr; 91(2-3):235-42. Epub 2006 Feb 24.
  • Caligiuri MP, Teulings HL, Dean CE, Niculescu AB, Lohr JB (2010) Handwriting movement kinematics for quantifying EPS in patients treated with atypical antipsychotics. Psychiatry Research 77(1-2):77-83
  • Mittal VA, Dean DJ, Pelletier A, Caligiuri MP (2011) Associations between spontaneous movement abnormalities and psychotic-like experiences in the general population. Schizophrenia Research doi: 10.1016/j.schres.2011.06.028
  • Caligiuri MP, Mohammed, LA, Rogers D, Found B (2012) Nonadherence to the Isochrony Principle in Forged Signatures. Forensic Science International 223:228-232.
  • Lohr JB, May T, Caligiuri MP (2012) Quantitative assessment of motor abnormalities in untreated patients with major depressive disorder. J Affect Disord. Sep 14. pii: S0165-0327(12)00614-3. doi: 10.1016/ j.jad.2012.08.043. [Epub ahead of print]
  • Caligiuri MP, Teulings HL, Dean CE, Niculescu AB, Lohr JB (2010) Handwriting movement kinematics for quantifying EPS in patients treated with atypical antipsychotics. Psychiatry Research 177: 77-83
  • Caligiuri MP, Mohammed LA (2012) The Neuroscience of Handwriting: Applications for Forensic Document Examination. CRC Press, Boca Raton; 247 pages
  • Caligiuri MP, Chi, K, Landy KM. Kinematic Analyses of Signature Writing in Healthy Aging. Journal of Forensic Sciences 2014 doi:10/1111/1556-4029.12437