Scott C. Matthews, M.D. 

Assistant Professor-in-Residence


Contact Information

T: (858) 642-1242
F: (858) 642-6442


After receiving his MD from UMDNJ-New Jersey Medical School in 1998, Dr. Matthews completed his internship and residency in psychiatry at UC San Diego, and was Chief Resident at UC San Diego Outpatient Psychiatric Services in his final year of residency. He then completed formal research training in functional brain imaging in mood disorders in UCSD’s Fellowship in Biological Psychiatry and Neuroscience. He is currently Assistant Adjunct Professor of Psychiatry at UC San Diego. Dr. Matthews is actively involved in the American Psychosomatic Society, and has served on several committees of this organization.

Research Interests

Research Focus

Dr. Matthews uses fMRI to study the neural substrates involved in mood disorders. He has published several articles that describe the involvement of the anterior cingulate cortex in cognitive processing and autonomic nervous system regulation. Dr. Matthews has received early academic career funding to implement these paradigms in patients with current major depressive disorder. His current work involves using cognitive and emotional tasks during fMRI to probe the neural circuitry involved in major depression and related mood disorders.

Clinical Focus

Dr. Matthews is a Staff Psychiatrist at VA San Diego Healthcare System where he is Chief of the Consultation Liaison Division of the VA Psychiatry Service. He also provides care for veterans in one of the VA’s outpatient mood clinics. Dr. Matthews is actively involved in teaching residents and medical students.


  • Matthews SC, Paulus MP, Simmons AN, Nelesen RA, Dimsdale JE: Functional subdivisions within anterior cingulate cortex and their relationship to autonomic nervous system function. Neuroimage 2004;22:1151-1156
  • Matthews SC, Simmons AN, Lane, SD, Paulus MP: Selective activation of the nucleus accumbens during risk-taking decision-making. Neuroreport 2004;15(13):2123-2127
  • Matthews SC, Paulus MP, Dimsdale JE: The contribution of functional neuroimaging to understanding neuropsychiatric side effects of interferon in hep C. Psychosomatics 2004;45(4):281-286
  • Matthews SC, Nelesen RA, Dimsdale JE: Depressive Symptoms are Associated With Increased Systemic Vascular Resistance to Stress. Psychosomatic Medicine 2005; 67:509-513
  • Matthews SC, Simmons AN, Arce E, Paulus MP: Dissociation of inhibition from error processing using a parametric inhibitory task during functional magnetic resonance imaging. Neuroreport 2005;16(7):755-760