9500 Gilman Drive M/C 0115
University of California, San Diego
La Jolla, CA 92093-0115 USA
T: (858) 534-1548
Dr. Jernigan trained as a clinical and experimental neuropsychologist, and since the late 1970’s has studied the human brain using imaging. This work has focused on brain development and aging, neurodevelopmental disorders, neuropsychiatric and substance use disorders, and neurodegenerative disorders. Since 2008 her central research interest has been the developing human mind and brain, and she has pursued this interest in collaboration with an interdisciplinary team as Director of the Center for Human Development. She also directs the Coordinating Center for the PING Project – a publicly shared imaging genomics data resource with imaging, neurocognition, and whole genome genotyping data from over 1500 children aged 3 to 20 years. She is a member of the National Advisory Board on Drug Abuse and serves on the scientific advisory boards of several research organizations in the US and Europe.
Current Research Focus:
- The developing behavioral phenotype (individuality): roles of genetics, brain development, experience, learning, and the dynamic interactions among these factors.
- Translation of findings from basic developmental and learning sciences to innovative practices at home, in schools, and in the clinic to prevent adverse outcomes in children.
Other Research Interests (past and present):
Imaging studies of brain development and brain aging; risk phenotypes for substance use disorders in youth; effects of prematurity on brain development; effects of drug and alcohol exposure, and of HIV infection, prenatally, during adolescence, and in adult populations; neural bases of neuropsychiatric, neurodevelopmental, and dementing disorders.
- Giménez M, Miranda MJ, Born AP, Nagy Z, Rostrup E, Jernigan TL. Accelerated cerebral white matter development in preterm infants: A voxel-based morphometry study with diffusion tensor MR imaging. NeuroImage, 2008, 41(3), 728-34.
- Madsen SK, Baare WFC, Hansen MV, Skimminge A, Ejersbo LR, Ramsøy TZ, Gerlach C, Åkeson P, Paulson OB, Jernigan TL. Response inhibition is associated with white matter microstructure in children. Neuropsychologia, 2010 Mar;48 (4):854-62.
- Vestergaard M, Madsen KS, Baare WFC, Skimminge A, Ejersbo LR, Ramsøy TZ, Gerlach C, Åkeson P, Paulson OB, Jernigan TL. White matter microstructure in superior longitudinal fasciculus associated with spatial working memory performance in children. Journal of Cognitive Neuroscience, J Cogn Neurosci. 2011 Sep;23(9):2135-46.
- Stiles J, Jernigan TL. The basics of brain development. Neuropsychol Rev, 2010, 20, 327–348. PMCID: 2989000.
- Jernigan TL, Archibald SA, Fennema-Notestine C, Taylor MJ, Theilmann RJ, Julaton M, Notestine RJ, Letendre SL, Ellis RJ, Heaton RK, Gamst AC, Franklin, Jr DR, Clifford DB, Collier AC, Gelman BB, Marra C, McArthur JC, McCutchan JA, Morgello S, Simpson DM, and Grant I for the CHARTER Group. Clinical factors related to brain structure in an HIV-infected cohort: The CHARTER Study. J Neurovirol, 2011, 17 (3), 248–257.
- Madsen KS, Baaré WFC, Skimminge A, Vestergaard M, Siebner HR, Jernigan TL. Brain microstructural correlates of visuospatial choice reaction time in children. NeuroImage (2011), Oct 15;58(4):1090-100.
- Madsen KS, Jernigan TL, Iversen P, Frøkjær VG, Mortensen EL, Knudsen GM, Baaré WFC. Cortisol awakening response and negative emotionality linked to asymmetry in major limbic fibre bundle architecture. Psychiatry Res. 2012 Jan 30;201(1):63-72. Epub 2012 Jan 30. PMID: 22285720
- Chen C-H, Gutierrez ED, Thompson W, Panizzon MS, Jernigan TL, Eyler LT, Fennema-Notestine C, Jak AJ, Neale MC, Franz CE, Lyons MJ, Grant MD, Fischl B, Seidman LJ, Tsuang MT,. Kremen WS, and Dale AM. Hierarchical genetic organization of human cortical surface area. Science. 2012 Mar 30;335(6076):1634-6. PMCID: 3690329.
- Archibald S, Jacobson MW, Fennema-Notestine C, Ogasawara M, Woods SP, Letendre S, Grant I, Jernigan TL. Functional interactions of HIV-infection and methamphetamine dependence during motor programming. Psychiatry Res. 2012 May 16. [Epub ahead of print] PMID: 22608157. PMCID: 3380171
- Klarborg B, Madsen KS, Hansen M, Skimminge A, Jernigan TL, Baaré WFC. Sustained attention is associated with right superior longitudinal fasciculus and superior parietal white matter microstructure in children. Human Brain Mapping 2012 Jul 17. doi: 10.1002/hbm.22139. [Epub ahead of print]
- Madsen KS, Jernigan TL, Iversen P, Frøkjær VG, Mortensen EL, Knudsen GM, Siebner HR, Baaré WFC. Hypothalamic-pituitary-adrenal axis tonus is associated with hippocampal microstructural asymmetry. NeuroImage. 2012 Jul 6;63(1):95-103. [Epub ahead of print]
- Brown TT, Kuperman JM, Chung Y, Erhart M, McCabe C, Hagler, Jr. DJ, Venkatraman VK, Akshoomoff N, Amaral DG, Bloss CS, Casey BJ, Chang L, Ernst TM, Frazier JA, Gruen JR, Kaufmann WE, Kenet T, Kennedy DN, Murray SS, Sowell ER, Jernigan TL, Dale AM, for the Pediatric Imaging, Neurocognition, and Genetics Study. Neuroanatomical assessment of biological maturity. Current Biology, 2012, Sep 25;22(18):1693-8. PMCID: PMC3461087
- Brown TT, Jernigan TL Brain development during the preschool years. Neuropsychol Rev, 2012 Dec;22(4):313-33, PMID: 23007644. PMCID: 3511633.
- Fjell AM, Walhovd KB, Brown TT, Kuperman JM, Chung Y, Hagler Jr. DJ, Venkatraman V, Roddey C, Erhart M, McCabe C, Akshoomoff N, Amaral DG, Bloss CS, Libiger O, Darst BF, Schork NJ, Casey BJ, Chang L, Ernst TM, Gruen JR, Kaufmann WE, Kenet T, Frazier J, Murray SS, Sowell ER, van Zijl P, Mostofsky S, Jernigan TL, Dale AM for the Pediatric Imaging, Neurocognition, and Genetics Study. Multi Modal Imaging of the Self-Regulating Developing Brain. Proc Natl Acad Sci USA 2012 Nov 27;109(48):19620-5. PMCID: 3511748.
- Akshoomoff N, Newman E, Thompson WK, McCabe C, Bloss CS, Chang L, Amaral DG, Casey BJ, Ernst TM, Frazier JA, Gruen JR, Kaufmann WE, Kenet T, Kennedy DN, Libiger O, Mostofsky S, Murray SS, Sowell ER, Schork N, Dale AM, and Jernigan TL for the Pediatric Imaging, Neurocognition, and Genetics Study. The NIH Toolbox Cognition Battery: Results from a Large Normative Developmental Sample (PING). Neuropsychology. 2013 Nov 11. [Epub ahead of print] NIHMSID: NIHMS541520