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Neuronal cell fate detemination
The expression of regulatory genes is manipulated in living chick embryos using microsurgery and electroporation and the effects on neural marker genes studied
Molecular mechanisms of gene regulation
Target DNA binding sites of neural transcription factors are biochemically characterized and findings coordinated with sequence data from the mouse and human genomes
Targeted misexpression of regulatory genes
Transgenic and knockout mouse technology is used to misexpress genes of interest, and the effects on neural marker genes, axonal growth, and cell survival studied.
Global analysis of neural gene expression
Micro-arrays (“GeneChips”) are employed in conjunction with other areas of study to understand the coordinated regulation of gene expression in the nervous system
 
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
     
   
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