Research
Areas
| Neuronal cell fate detemination |  |
The
expression of regulatory genes is manipulated in living chick embryos
using microsurgery and electroporation and the effects on neural
marker genes studied |
|
| Molecular mechanisms of gene regulation |  |
| Target
DNA binding sites of neural transcription factors are biochemically
characterized and findings coordinated with sequence data from the
mouse and human genomes |
|
| Targeted misexpression of regulatory genes |  |
Transgenic
and knockout mouse technology is used to misexpress genes of interest,
and the effects on neural marker genes, axonal growth, and cell
survival studied. |
|
| Global analysis of neural gene expression |  |
| Micro-arrays
(“GeneChips”) are employed in conjunction with other
areas of study to understand the coordinated regulation of gene
expression in the nervous system |
