NEUROBIOLOGY OF COMPULSIVE HOARDING
Sanjaya Saxena, M.D.
Associate Professor, UCSD Department of Psychiatry
Director, UCSD Obsessive-Compulsive Disorders Program
Dr. Sanjaya Saxena, director of the UCSD
Obsessive-Compulsive Disorders Program, is conducting a research
study to identify abnormalities of brain structure and function in
individuals with Compulsive Hoarding, compared to other people with
Obsessive Compulsive Disorder (OCD) and volunteers with no
psychiatric disorder, and to determine how brain function may change
with effective treatment. This study is sponsored by the National
Institute of Mental Health. Study participants will receive:
Brain imaging, which is a way of taking pictures
of brain structure and function through techniques called positron
emission tomography (PET) and Magnetic Resonance Imaging (MRI).
12 weeks of treatment with venlafaxine (Effexor
XR) an FDA approved medication (no placebos).
Neuropsychological testing, which includes
testing of your attention, memory, thinking, and decision-making,
before and after treatment.
To participate, you must either live in or near San Diego, or be
able to travel easily to our center for all procedures and treatment
appointments. Participants must meet the inclusion criteria for this
Meet DSM-IV criteria for a primary diagnosis
of OCD, Compulsive Hoarding, or BDD.
Between the ages of 18-65
Free of all psychotropic medications for at
least 4 weeks (and at least 5 weeks for long half-life
medications such as fluoxetine) prior to initiating the study.
All subjects must be considered clinically
appropriate for primary treatment with venlafaxine by the study
All subjects must be fluent in English and
competent to sign informed consent.
Individuals will be excluded from participation
Are currently taking medications that affect
brain function, such as antidepressants, anti-anxiety drugs,
antipsychotics, certain antihypertensives, insulin, thyroid
Have bipolar disorder, schizophrenia,
post-traumatic stress disorder (PTSD), panic disorder, autism,
mental retardation, or an eating disorder.
Have a neurological disorder, such as
epilepsy, Parkinson’s disease, stroke, traumatic brain injury,
Have a history of chronic alcohol or
Weigh over 280 pounds.
There is NO monetary compensation for this study.
If interested, please contact Dr. Jennifer
Sumner at 858-534-8056.
For clinical treatment, please contact:
UCSD Obsessive - Compulsive Disorders Clinic
La Jolla Village Professional Center
8950 Villa La Jolla Drive, Suite B225
La Jolla, CA 92037