Biography 
Dr. Jeste is Director of NIMH-funded Advanced Center for Interventions and Services Research at UCSD, focusing on psychosis in late-life. He is also the Principal Investigator on several research and training grants, including Summer Research Institute in Geriatric Psychiatry, a national research training program. Following medical education in India, Dr. Jeste completed psychiatry and neurology residencies at Cornell and George Washington University, respectively. He was Chief of Units on Movement Disorders and Dementias at NIMH before joining UCSD in 1986. He has been President of the American Association of Geriatric Psychiatry, and International College of Geriatric Psychoneuropharmacology, and is Editor of the American Journal of Geriatric Psychiatry.

Research Focus 
Dr. Jeste’s primary areas of research are psychosis and its treatment in late life. He has conducted studies of clinical, neuropsychological and neurobiological characteristics of Late-Onset Schizophrenia, Aging of Early-Onset Schizophrenia Patients, and Psychosis of Alzheimer disease. In terms of treatments, he has published on therapeutic and adverse effects (especially tardive dyskinesia) of antipsychotics. He has also been interested in psychosocial treatments as well as certain bioethical aspects of research (particularly decision making capacity and methods for enhancing it) among older people with psychotic disorders. In recent years, he has been seeking to understand mechanisms for overcoming serious mental illness in old age.

Clinical Focus 
Dr. Jeste started the Geriatric Psychiatry program at UCSD in 1986. Two key components of the Division of Geriatric Psychiatry are Senior Behavioral Health program (with inpatient unit and outpatient clinic) at UCSD Medical Center, and Geriatric Psychiatry Clinic at VA San Diego Healthcare System. Both these multi-disciplinary programs serve older persons with various neuropsychiatric disorders including dementia, depression, schizophrenia, alcohol and substance use disorders, and anxiety disorders. Patients receive psychiatric, medical and neuropsychologic assessments. Treatments include pharmacotherapy, psychosocial therapy, and family education/therapy with caregivers. There are also several training programs in geriatric mental health.

Selected Publications 

• Jeste DV, Caligiuri MP, Paulsen JS, Heaton RK, Lacro JP, Harris MJ, Bailey A, Fell RL and McAdams LA: Risk of tardive dyskinesia in older patients: A prospective longitudinal study of 266 outpatients. Archives of General Psychiatry, 52:756-765, 1995.
• Jeste DV, Symonds LL, Harris MJ, Paulsen JS, Palmer BW and Heaton RK: Non-dementia non-praecox dementia praecox?: Late-onset schizophrenia. American Journal of Geriatric Psychiatry 5(4):302-317, 1997.
• Jeste DV, Alexopoulos GS, Bartels SJ, Cummings JL, Gallo JJ, Gottlieb GL, Halpain MC, Palmer BW, Patterson TL, Reynolds CF and Lebowitz BD: Consensus statement on the upcoming crisis in geriatric mental health: Research agenda for the next two decades. Archives of General Psychiatry, 56:848-853, 1999.
• Paulsen JS, Salmon DP, Thal LJ, Romero R, Weisstein-Jenkins C, Galasko D, Hofstetter CR, Thomas R, Grant I and Jeste DV: Incidence of and risk factors for hallucinations and delusions in patients with probable AD. Neurology, 54: 1965-1971, 2000.
• Heaton RK, Gladsjo JA, Palmer BW, Kuck J, Marcotte TD and Jeste DV: Stability and course of neuropsychological deficits in schizophrenia. Archives of General Psychiatry 58:24-32, 2001.