Ian Paul Everall Bsc (Hons) M.B., ChB (Hons), MRCPsych, FRCPath, Ph.D.
Professor of Psychiatry
Phone#: 858-822-1878
FAX #: 858-534-7653
E-mail: ieverall@ucsd.edu
 

Biography
Dr Everall undertook his medical education at Leicester University School of Medicine. From there he trained in psychiatry at the Bethlem Royal and Maudsley Hospitals in South London. In 1989 he obtained Membership of the Royal College of Psychiatrists and a MRC Clinical Research Training Fellowship, followed in 1992 by an advanced MRC Clinician Scientist Fellowship to undertake neuropathological research on psychiatric disorders at the Department of Neuropathology, Institute of Psychiatry. He obtained his Ph.D. in 1992. In 1993 he was appointed Senior Lecturer at the Institute of Psychiatry, Honorary Senior Lecturer, Kings College School of Medicine London, and Honorary Consultant Psychiatrist at The Maudsley Hospital to run an HIV Liaison Psychiatry Service. In 1999 he was appointed Professor of Experimental Neuropathology and Psychiatry at the Institute of Psychiatry, King’s College London. In 2003 he was made a Fellow of the Royal College of Pathologists. In 2004 he was appointed Professor of Psychiatry at the University of California, San Diego.

Research Focus
Dr. Everall’s primary research focus is to investigate the cellular and molecular neuropathology of disorders relevant to psychiatry. Within the field of HIV and neuroscience Dr Everall identified that HIV infection of the brain resulted in neuronal death and with colleagues at the HIV Neurobehavioral Research Center, UCSD, he correlated the pathological changes with neurocognitive impairment. More recently he has been investigating avenues for neuroprotection and assessing how well various antiretroviral agents suppress viral replication in the human brain.

Dr. Everall has also investigated the neuropathological changes associated with schizophrenia, major depression and bipolar disorder. This has involved undertaking detailed stereological quantitation of cellular changes in these disorders and examining various neurodevelopmental pathways and noting abnormalities in the expression of components of these pathways in the brain in schizophrenia. In addition, he has been undertaking in vitro assessments of the cellular and genetic changes associated with antidepressants and antipsychotic medication.

Clinical Focus
Liaison psychiatry for individuals with ongoing medical disorders including HIV disease. Assessment and treatment of affective disorders.

Selected Publications

• Chana G, Landau S, Beasley C, Everall IP, Cotter D.(2003) Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: evidence for decreased neuronal somal size and increased neuronal density. Biol Psychiatry; 53: 1086-98.
• Pennington K, McGregor E, Beasley CL, Everall I, Cotter D, Dunn MJ. Optimization of the first dimension for separation by two-dimensional gel electrophoresis of basic proteins from human brain tissue. Proteomics. 2004;4:27-30.
• Beasley, C., Cotter, D., Everall, I.P. (2002) Density and distribution of white matter neurons in schizophrenia, bipolar disorder and major depressive disorder: no evidence for abnormalities of neuronal migration. Mol Psychiatry; 7 (6) 564-70.
• Ilia M, Beasley C, Meijer D, Kerwin R, Cotter D, Everall I, Price J.(2002) Expression of Oct-6, a POU III domain transcription factor, in schizophrenia. Am J Psychiatry; 159:1174-82.
• Everall IP, Bell C, Mallory M, Langford D, Adame A, Rockestein E, Masliah E.(2002) Lithium ameliorates HIV-gp120-mediated neurotoxicity. Mol Cell Neurosci.; 21: 493-501.