John R. Kelsoe, M.D.
Professor of Psychiatry
9500 Gilman Drive
La Jolla, CA 92093-0603
Phone #: 858-534-5927
FAX #: 858-534-5527
E-mail: jkelsoe@ucsd.edu
Web site:
http://psychgenes.ucsd.edu
Biography
Dr. Kelsoe graduated from medical school at the University of
Alabama, Birmingham in 1981. He completed internship training
at Washington University in St. Louis and psychiatry residency
at UCSD. He then went to the National Insititue of Mental
Health in Bethesda, Maryland for 4 years and returned to San
Diego to join the Dept. of Psychiatry faculty in 1989.
Research Focus
Dr. Kelsoe’s longstanding research focus has been the genetics
of psychiatric illness, bipolar disorder in particular. Over
the past 15 years, his work has been focused on using a
variety of molecular genetic methods to identify the specific
genes that predispose to bipolar disorder. He has pursued this
primarily by using positional cloning methods such as linkage
and association in families in which the illness is
genetically transmitted. He has also employed animal models of
bipolar disorder in order to identify possible candidate genes
that can then be tested in clinical populations. This approach
has led to the recent identification of the gene for G protein
receptor kinase 3 (GRK3) as a likely gene for bipolar disorder
on chromosome 22.
Clinical Focus
Dr. Kelsoe’s primary clinical focus is the treatment of
refractory mood disorders. He is the Medical Director of the
STEP Clinic at the VA Hospital where they specialize in the
treatment of chronic and refractory mood disorders. Patients
at this clinic receive a thorough diagnostic evaluation and
are eligible to participate in longitudinal research studies
of the ability of genes to predict course, outcome, and
treatment response.
Selected Publications
- Barrett TB, Hauger RL, Kennedy JL, Sadovnick AD, Remick RA,
Keck PE, McElroy SL, Alexander M, Shaw SH, Kelsoe JR. Evidence
that a single nucleotide polymorphism in the promoter of the G
protein receptor kinase 3 gene is associated with bipolar
disorder. Molecular Psychiatry, 8:546-557, 2003.
- Kelsoe JR, Spence MA, Loetscher E, Foguet M, Sadovnick AD,
Remick RA, Flodman P, Khristich J, Mroczkowski-Parker Z, Brown
JL, Masser D, Ungerleider S, Rapaport MH, Wishart WL, Luebbert
H. Genome Survey Indicates a Susceptibility Locus for Bipolar
Disorder on Chromosome 22. Proceedings of the National Academy
of Sciences 98:585-590, 2001.
- Greenwood TA,
Alexander M, Keck PE, McElroy S, Sadovnick AD, Remick RA,
Kelsoe JR. Evidence for Linkage Disequilibrium between the
Dopamine Transporter and Bipolar Disorder. Am J Med Genet (Neuropsychiatric
Genetics)105:145-151, 2001.
- Niculescu AB,
Segal DS, Kuczenski R, Barrett T, Hauger RL, Kelsoe JR. Identifying candidate genes for mania and psychosis: a
convergent functional genomics approach. Physiological
Genomics 4:83-91, 2000.
- Kelsoe JR, Ginns EI,
Egeland JA, Gerhard DS, Goldstein AM, Bale SJ, Pauls DL, Long
RT, Kidd KK, Conte G, Housman DE and Paul SM. Reevaluation of
the Linkage Relationship between Chromosome 11p Loci and the
Gene for Bipolar Affective Disorder in the Old Order Amish.
Nature 342:238-243, 1989.
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