John R. Kelsoe, M.D.
Professor of Psychiatry
9500 Gilman Drive
La Jolla, CA 92093-0603
Phone #: 858-534-5927
FAX #: 858-534-5527
E-mail: jkelsoe@ucsd.edu
Web site:
http://psychgenes.ucsd.edu
Biography
Dr. Kelsoe graduated from medical school at the University
of Alabama, Birmingham in 1981. He completed internship
training at Washington University in St. Louis and
psychiatry residency at UCSD. He then went to the National
Institute of Mental Health in Bethesda, Maryland for 4 years
and returned to San Diego to join the Department of
Psychiatry faculty in 1989.
Research Focus
Dr. Kelsoe’s longstanding research focus has been the
genetics of psychiatric illness, bipolar disorder in
particular. Over the past 20 years, his work has been
focused on using a variety of molecular genetic methods to
identify the specific genes that predispose to bipolar
disorder. He has pursued this primarily by using positional
cloning methods such as linkage and association in families
in which the illness is genetically transmitted. He has also
employed animal models of bipolar disorder in order to
identify possible candidate genes that can then be tested in
clinical populations. This approach has led to the recent
identification of the gene for G protein receptor kinase 3
(GRK3) as a likely gene for bipolar disorder on chromosome
22. Dr. Kelsoe is currently actively engaged in genome wide
association studies of bipolar disorder. He directs the
Bipolar Genome Study (BiGS) which is a 13-site consortium
focused on identifying genes for bipolar disorder and their
relationship to clinical symptoms. He also co-directs the
Psychiatric GWAS Consortium for Bipolar Disorder (PGC-BD)
which is an international collaborative effort designed to
identify genes for bipolar disorder in a sample of over
10,000 patients. These large exciting new technological
approaches promise great advances in understanding the
causes of bipolar disorder. Clinical Focus
Dr. Kelsoe’s primary clinical focus is the treatment of
refractory mood disorders. He is the Medical Director of the
STEP Clinic at the VA Hospital where they specialize in the
treatment of chronic and refractory mood disorders. Patients at
this clinic receive a thorough diagnostic evaluation and are
eligible to participate in longitudinal research studies of the
ability of genes to predict course, outcome, and treatment
response.
Selected Publications
- Barrett TB, Hauger RL, Kennedy JL, Sadovnick AD, Remick RA,
Keck PE, McElroy SL, Alexander M, Shaw SH, Kelsoe JR. Evidence
that a single nucleotide polymorphism in the promoter of the G
protein receptor kinase 3 gene is associated with bipolar
disorder. Molecular Psychiatry, 8:546-557, 2003.
- Kelsoe JR, Spence MA, Loetscher E, Foguet M, Sadovnick AD,
Remick RA, Flodman P, Khristich J, Mroczkowski-Parker Z, Brown
JL, Masser D, Ungerleider S, Rapaport MH, Wishart WL, Luebbert
H. Genome Survey Indicates a Susceptibility Locus for Bipolar
Disorder on Chromosome 22. Proceedings of the National Academy
of Sciences 98:585-590, 2001.
- Greenwood TA,
Alexander M, Keck PE, McElroy S, Sadovnick AD, Remick RA,
Kelsoe JR. Evidence for Linkage Disequilibrium between the
Dopamine Transporter and Bipolar Disorder. Am J Med Genet (Neuropsychiatric
Genetics)105:145-151, 2001.
- Niculescu AB,
Segal DS, Kuczenski R, Barrett T, Hauger RL, Kelsoe JR. Identifying candidate genes for mania and psychosis: a
convergent functional genomics approach. Physiological
Genomics 4:83-91, 2000.
- Kelsoe JR, Ginns EI,
Egeland JA, Gerhard DS, Goldstein AM, Bale SJ, Pauls DL, Long
RT, Kidd KK, Conte G, Housman DE and Paul SM. Reevaluation of
the Linkage Relationship between Chromosome 11p Loci and the
Gene for Bipolar Affective Disorder in the Old Order Amish.
Nature 342:238-243, 1989.
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