John R. Kelsoe, M.D.
Professor of Psychiatry
9500 Gilman Drive
La Jolla, CA 92093-0603
Phone #: 858-534-5927
FAX #: 858-534-5527
E-mail: jkelsoe@ucsd.edu
Web site:
http://psychgenes.ucsd.edu
Biography
Dr. Kelsoe graduated from medical school at the University
of Alabama, Birmingham in 1981. He completed internship
training at Washington University in St. Louis and
psychiatry residency at UCSD. He then went to the National
Institute of Mental Health in Bethesda, Maryland for 4 years
and returned to San Diego to join the Department of
Psychiatry faculty in 1989.
Research Focus
Dr. Kelsoe’s longstanding research focus has been the
genetics of psychiatric illness, bipolar disorder in
particular. Over the past 20 years, his work has been
focused on using a variety of molecular genetic methods to
identify the specific genes that predispose to bipolar
disorder. He has pursued this primarily by using positional
cloning methods such as linkage and association in families
in which the illness is genetically transmitted. He has also
employed animal models of bipolar disorder in order to
identify possible candidate genes that can then be tested in
clinical populations. This approach has led to the recent
identification of the gene for G protein receptor kinase 3
(GRK3) as a likely gene for bipolar disorder on chromosome
22. Dr. Kelsoe is currently actively engaged in genome wide
association studies of bipolar disorder. He directs the
Bipolar Genome Study (BiGS) which is a 13-site consortium
focused on identifying genes for bipolar disorder and their
relationship to clinical symptoms. He also co-directs the
Psychiatric GWAS Consortium for Bipolar Disorder (PGC-BD)
which is an international collaborative effort designed to
identify genes for bipolar disorder in a sample of over
10,000 patients. These large exciting new technological
approaches promise great advances in understanding the
causes of bipolar disorder. Clinical Focus
Dr. Kelsoe’s primary clinical focus is the treatment of
refractory mood disorders. He is the Medical Director of the
STEP Clinic at the VA Hospital where they specialize in the
treatment of chronic and refractory mood disorders. Patients at
this clinic receive a thorough diagnostic evaluation and are
eligible to participate in longitudinal research studies of the
ability of genes to predict course, outcome, and treatment
response.
Selected Publications
- Joo EJ, Greenwood TA, Schork N, McKinney R, Sadovnick AD, Remick RA, Keck PE, McElroy SL, Kelsoe JR. Suggestive evidence for linkage of ADHD features in bipolar disorder to chromosome 10p14. Am J Med Genet B Neuropsychiatr Genet, 9999:1–9, 2009 Jul 14 PMID: 19603423
- Smith EN, Bloss CS, Badner JA, Barrett T, Belmonte PL, Berrettini W, Byerley W, Coryell W, Craig D, Edenberg HJ, Foroud T, Gabriel SB, Gershon E, Greenwood TA, Hipolito M, Koller DL, Lawson WB, Liu C, Lohoff F, McInnis MG, McMahon FJ, Mirel DB, Nievergelt C, Nurnberger J, Nwulia EA, Paschall J, Potash JB, Rice J, Schulze TG, Scheftner W, Panganiban C, Zaitlen N, Zandi PP, Zöllner S, Schork NJ, Kelsoe JR. Genome-wide association study of bipolar disorder in European American and African American individuals. Mol Psychiatry, 2009 Aug;14(8):755-63 PMID: 19488044
- Zhou X, Tang W, Greenwood TA, Guo S, He L, Geyer MA, Kelsoe JR. Transcription Factor SP4 is a susceptibility gene for bipolar disorder. PLoS ONE 2009 4(4):e5196, PMCID: PMC2674320
- McCarthy MJ, Barrett TB, Nissen S, Kelsoe JR, Turner EE. Allele specific analysis of the ADRBK2 gene in lymphoblastoid cells from bipolar disorder patients. J Psychiatr Res, 2009 Sep 17 PMID: 19766236
- Oedegaard KJ, Greenwood TA, Lunde A, Fasmer OB, Akiskal HS, Kelsoe JR, NIMH Genetics Initiative Bipolar Disorder Consortium. 2009 A genome-wide linkage study of bipolar disorder and co-morbid migraine: Replication of migraine linkage on chromosome 4q24, and suggestion of an overlapping susceptibility region for both disorders on chromosome 20p11. J Affec Disord, 2009 Oct 10 PMID: 19819557
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