Lisa T. Eyler, Ph.D.
Associate Adjunct Professor
Mail Code 151B
3500 La Jolla Village Drive
San Diego, CA 92161
Phone #: 858-552-8585, Ext. 7666
Fax: 858-642-1458

Bipolar Aging and Imaging Study

Dr. Eyler received her undergraduate degree from Duke University in 1991 and her Ph.D. in clinical psychology from the University of Pennsylvania in 1996. She then completed a clinical psychology internship at UCSD and the San Diego VA, with a focus on neuropsychological assessment and adult outpatient psychotherapy. From 1997-1999, she was a post-doctoral fellow in Geriatric Psychology under the mentorship of Dilip Jeste, M.D. and Gregory Brown, Ph.D. She then joined the faculty of the Desert-Pacific Mental Illness Research Education and Clinical Center (MIRECC) as a Research Health Scientist. In 2004, she was appointed an Assistant Adjunct Professor in the UCSD Department of Psychiatry, and, in 2010, became an Associate Adjunct Professor. Dr. Eyler also is a VA-privileged Clinical Research Psychologist in the MIRECC program and directs the VA Advanced Psychology Post-Doctoral Fellowship program. In addition, she serves as a faculty member in the SDSU/UCSD Joint Doctoral Program in Clinical Psychology and the Stein Institute for Research on Aging. Dr. Eyler’s research program is currently supported by several NIH grants on which she is an investigator, including an R01 grant from NIMH entitled "Structural and Functional Brain Aging in Bipolar Disorder" on which she is Principal Investigator. 

Research Focus:
Dr. Eyler's research focuses on understanding individual differences in cognitive and emotional functioning using structural and functional brain imaging.  In particular, she has examined the relationship between cognitive deficits in schizophrenia and abnormalities of brain function and how these relationships may change with age.  Her current NIMH-funded R01 project aims to examine whether brain structure and function appear to age more rapidly among individuals with bipolar disorder and how this may relate to increasing cognitive deficits with age.  Dr. Eyler is also a co-investigator in the Autism Center of Excellence at UCSD and is involved in studies that aim to discover a bio-behavioral fingerprint of autism at a very young age by combining neuroimaging, behavioral, and genetic measures in infants and toddlers at risk for autism to improve diagnostic predictions and better understand the developmental etiology of the disorder.  Dr. Eyler also has an interest in healthy aging and has conducted studies examining the relationship of cognitive and emotional success to brain function among healthy seniors, and she is a co-investigator on the Vietnam Era Twin Study of Aging MRI study which aims to understand genetic and environmental contributions to brain aging and its association with cognitive and emotional functioning.  

Clinical Focus:
Dr. Eyler is a licensed clinical psychologist with training in neuropsychological and diagnostic assessment and adult outpatient psychotherapy.

Selected Publications:

  • Eyler Zorrilla LT, Heaton RK, McAdams L, Zisook S, Harris MJ, Jeste DV. Cross-sectional study of older outpatients with schizophrenia and healthy comparison subjects: No differences in age-related cognitive decline. Am. J. Psychiatry. 2000;157:1324-1326.
  • Eyler Zorrilla LT, Jeste DV, Paulus M, Brown GG. Functional abnormalities of medial temporal cortex during novel picture learning among patients with chronic schizophrenia. Schizophrenia Research. 2003; 59:187-198.
  • Eyler LT, Jeste DV, Brown GG. Brain response abnormalities during verbal learning among patients with schizophrenia. Psychiatry Res. 2008;162(1):11-25.
  • Eyler LT, Kaup AR, Mirzakhanian HM, Jeste DV. Schizophrenia patients lack normal positive correlation between age and brain response during verbal learning. Am J Geriatr Psychiatry. 2009;17(1):43-55.
  • Eyler LT, Prom-Wormley E, Fennema-Notestine C, Panizzon MS, Neale MC, Jernigan TL, Fischl B, Franz CE, Lyons MJ, Stevens A, Pacheco J, Perry ME, Schmitt JE, Spitzer NC, Seidman LJ, Thermenos HW, Tsuang MT, Dale AM, Kremen WS. Genetic patterns of correlation among subcortical volumes in humans: Results from a magnetic resonance imaging twin study. Hum Brain Mapp. 2010.


University of California, San Diego, Department of Psychiatry, 9500 Gilman Drive, Mail Code 0603 La Jolla, CA 92037-0603
Telephone: (858) 534-3684, Fax: (858) 534-7653, Electronic Mail: