William S. Kremen, Ph.D.
Professor
9500 Gilman Drive
La Jolla, CA 92093-0603
PHONE: 858-822-2393
FAX: 858-822-5856
E-mail:wkremen@ucsd.edu

Biography
Dr. Kremen received his Ph.D. in Clinical Psychology from Boston University in 1990. He completed his Clinical Internship at Harvard Medical School where he remained as a faculty member until joining the faculty at UC Davis in 1996. He has been Professor of Psychiatry at UCSD since 2003 and is also a member of the Institute of Behavioral Genomics and the Stein Institute for Research on Aging. He currently has federal grant funding for a series of behavioral genetic studies of biological and psychosocial aspects of aging.

Research Focus
Dr. Kremen has research programs on schizophrenia and aging, both of which integrate behavioral genetic research strategies with clinical and neuroscience approaches. His aging research includes three federally-funded longitudinal twin studies aimed at developing a comprehensive understanding of successful and maladaptive aging. These studies use genetic epidemiological methods to determine genetic and environmental influences on different dimensions of aging in several hundred twin pairs. The following domains are examined: 1) neurocognitive function; 2) personality and psychosocial factors; 3) psychopathology; 4) health and medical factors; 5) genotyping; 6) neuroimaging; and 7) HPA axis/neuroendocrine function. His schizophrenia research includes family and twin studies that focus on: 1) identifying neuropsychological and brain indicators of vulnerability; 2) understanding the course of neurocognitive function in schizophrenia; and 3) gene expression.

Selected Publications:

• Kremen, W.S., Buka, S.L., Seidman, L.J., Goldstein, J.M., Koren, D., and Tsuang, M.T. (1998). IQ decline during childhood and adult psychotic symptoms in a community sample: A 19-year longitudinal study. American Journal of Psychiatry 155:672-679.
• Kremen, W.S., Seidman, L.J., Faraone, S.V., Toomey, R., and Tsuang, M.T. (2000). The paradox of normal neuropsychological function in schizophrenia. Journal of Abnormal Psychology 109: 743-752.
• Kremen, W.S. and Hoff, A.L. Neurocognitive deficits in the biological relatives of individuals with schizophrenia, pp. 133-158. (2004). In Stone, W.S., Faraone, S.V., and Tsuang, M.T. (Eds.), Early Clinical Intervention and Prevention in Schizophrenia, Humana Press.
• Kremen, W.S., Jacobson, K.C., Xian, H., Eisen, S.A., Waterman, B., Toomey, R., Neale, M.C., Tsuang, M.T., and Lyons, M.J. (2005). Heritability of word recognition in middle-aged men varies as a function of parental education. Behavior Genetics 35: 417-433.
• Kremen, W.S., Lyons, M.J., Boake, C., Xian, H., Jacobson, K.C., Waterman, B., Eisen, S.A., Goldberg, J., Faraone, S.V., Tsuang, M.T. (in press). A discordant twin study of premorbid cognitive ability in schizophrenia. Journal of Clinical and Experimental Neuropsychology.