Newly Funded Grants

INVESTIGATING MECHANISMS OF INTRA- AND INTER-INDIVIDUAL PAIN VARIABILITY IN PATIENTS WITH COMORBID CHRONIC PAIN AND DEPRESSION 

DOP Researcher Name(s): PI: Matthew Herbert, PhD & Jyoti Mishra, PhD, MBA
Type of Grant: R01
Project Period: 05/29/2025 - 04/30/2028
Total Cost: $2,884,008
Funding Agency: NIH/NINDS
Abstract: Their groundbreaking project, “Investigating Mechanisms of Intra-and Inter-individual Pain Variability in Patients with Comorbid Chronis Pain and Depression” aims to transform how we understand and treat chronic low back pain and major depressive disorder. By combining brain and cognitive assessments, smartphone and wearable health data, with personalized machine learning, the team will develop unique individual pain prediction models and also identify distinct subgroups based on shared pain variability features — a major step toward precision mental health care. This innovative research holds the potential to reshape clinical approaches to chronic pain + depression and deepen our understanding of the biological + psychosocial mechanisms behind pain and mood disorders.

EXPRESSION OF CIRCULAR RNA BIOMARKERS IN TRD PATIENTS AND THE DEVELOPMENT OF PROGNOSIS MODELS

DOP Researcher Name(s): PI: Greg Appelbaum, PhD & Jeff Daskalakis, MD, PhD
Type of Grant: Circular Genomics
Project Period: 04/01/2025 –03/31/2027
Total Cost: $269,854
Funding Agency: Circular Genomics Inc.

LEVERAGING DIGITAL COGNITIVE RHYTHMS TO DETECT ADRD RISK IN FAMILY CAREGIVERS

DOP Researcher Name(s): PI: Raeanne Moore, PhD 
Type of Grant: AI/Tech + Aging (a2) Collective Pilot Funding
Project Period: 02/15/2025 - 02/14/2026
Total Cost: $249,864
Funding Agency: NIA/UMass Amherst AITC

BD² INTEGRATED NETWORK UC SAN DIEGO SITE

DOP Researcher Name(s): PI and Co-research Lead: Lisa T Eyler, PhD, Co-research Lead: Colin Depp, PhD, Clinical Lead: Michael McCarthy, MD, PhD, Research co-investigator: Federica Klaus, MD, PhD , Clinic faculty leads: Jessica Thackaberry, MD and Andres Schneeberger, MD
Type of Grant: Integrated Network
Project Period: 2025-2030
Total Cost: $2,300,000
Funding Agency: Breakthrough Discoveries for thriving with Bipolar Disorder (BD²)

Read more about the study.

MAINTENANCE RTMS FOR DEPRESSION (MAITR-DE)

DOP Researcher Name(s): PI: Jeff Daskalakis, MD, PhD
Type of Grant: R61
Project Period: 04/01/2025 –03/31/2027
Total Cost: $1,845,529
Funding Agency: NIMH

PSYCHEDELIC TREATMENT TO IMPROVE SOCIAL AND COGNITIVE FUNCTION IN PRECLINICAL MODELS OF SCHIZOPHRENIA

DOP Researcher Name(s): PI: Susan Powell, PhD, Co-Is: Sam Barnes, PhD, Adam Halberstadt, PhD
Type of Grant: VA Merit
Project Period: 04/01/2025- 03/31/2029
Total Cost: $1,433,716
Funding Agency: Veterans Affairs

GENOME-WIDE ASSOCIATION AND FINE-MAPPING OF SMOKING USING TANDEM REPEATS AND STRUCTURAL VARIANTS

DOP Researcher Name(s): PI: Abraham Palmer, PhD, Co-I: Sandra Sanchez-Roige, PhD
Type of Grant: Tobacco-Related Disease Research Program (TRDRP) Research Award
Project Period: 07/01/2025-06/30/2028
Total Cost: $1,215,000
Funding Agency: TRDRP

GENETIC, CLINICAL, BEHAVIORAL, AND ENVIRONMENTAL DETERMINANTS OF MATERNAL SMOKING AND MORBIDITY

DOP Researcher Name(s): PI: Natasia Courchesne-Krak, PhD, Co-Is: Sandra Sanchez-Roige, PhD & Carla Marienfeld, MD
Type of Grant: TRDRP 2025 - Single Investigator Maternal Cessation Award
Project Period: 07/01/2025-06/30/2027
Total Cost: $663,760
Funding Agency: TRDRP