ONEMIND Research Studies

1 - Neural Mechanisms of Meditation-Based Intervention for Chronic Low Back Pain (CLBP)

Summary

The study offers the chance to receive 8 weeks of a meditation-based therapy designed for those who have been diagnosed with chronic low back pain, and who are being treated with a prescription opioid medication. The purpose of this study is to understand the effectiveness of a meditation-based group treatment for people with chronic low back pain conditions.

Principal Investigator: Dr. Eric Garland (UC San Diego), Dr. Fadel Zeidan (UC San Diego)

2 - Motivational Interviewing And Mindfulness-Oriented Recovery Enhancement (MIAMORE)

Summary

This study aims to identify barriers and facilitators to implementing Motivational Interviewing (MI) and Mindfulness-Oriented Recovery Enhancement (MORE) for polysubstance use, while testing strategies to improve training, fidelity, and clinic adoption. It also evaluates how MORE impacts patient outcomes, including reductions in opioid, tobacco, and other drug use.

Principal Investigators: Dr. Eric Garland (UC San Diego), Dr. Nina Cooperman (Rutgers University)

3 - Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR)

Summary

A hybrid implementation-effectiveness trial testing Mindfulness-Oriented Recovery Enhancement (MORE) for patients with opioid use disorder receiving methadone treatment who are also experiencing chronic pain. The study compares a high-intensity MORE strategy, a brief scripted mindfulness practice (SMP), and treatment as usual (TAU) to evaluate outcomes such as opioid use, craving, and mental health. Investigators will also identify barriers and facilitators to implementing mindfulness-based interventions in methadone treatment and assess the sustainability of a train-the-trainer model.

Principal Investigators: Dr. Eric Garland (UC San Diego), Dr. Nina Cooperman (Rutgers University)

4 - Enhanced Pain Coping in Cancer (EPIC)

Summary

In partnership with Memorial Sloan Kettering Cancer Center (MSK), the Enhanced Pain Coping in Cancer Study (EPIC) investigates two different types of group therapy (Mindfulness Oriented Recovery Enhancement and supportive group therapy) to determine their effectiveness in helping breast cancer survivors manage their joint pain caused by aromatase inhibitors (AI). AI-associated arthralgia (AIA) and its associated symptoms can make some people decide to stop taking their medication; thus, the results of this study will show researchers whether these treatment approaches may be useful for managing AIA and cancer-related symptoms.

Principal Investigators: Dr. Eric Garland (UC San Diego), Dr. Jun Mao (Memorial Sloan Kettering Cancer Center)

5 - Optimizing Patient-Centered Chronic Pain Care (MIRHIQL)

Summary

In partnership with Rutgers University, the Optimizing Patient-Centered Chronic Pain Care study examines two approaches to help individuals with chronic pain who are prescribed long-term opioid therapy. The study compares standard chronic pain management visits to visits enhanced with a mindfulness-based program (Mindfulness Oriented Recovery Enhancement) to evaluate their effectiveness in improving pain relief, stress reduction, and overall well-being.

Principal Investigators: Dr. Eric Garland (UC San Diego), Dr. Nina Cooperman (Rutgers University)